Treatment of glaucoma associated with retinopathy of prematurity in children

Abstract

Objective.To present the results of hypotensive glaucoma surgery in children with retinopathy of prematurity (ROP).

Material and methods. An analysis of surgical hypotensive treatment of glaucoma in 6 (9 eyes) children with ROP aged from 1 month to 1 year was carried out in the eye department of the clinic of the Tashkent Pediatric Medical Institute. According to the stages and phases of ROP, patients were divided into 2 groups, the first included 3 (5 eyes) children with stages I–III of the active phase of the disease, the second – 3 children (4 eyes) with stages IV–V regressive (scar) phase. One patient had a bilateral process with stage V regressive phase with postoperative aniridia. The gestational age at birth of the examined children was 21–36 weeks. The duration of observation is 18 months. Taking into account echobiometric and gonioscopic characteristics, the type and volume of hypotensive surgical treatment were determined. In the first group, ab externa sinusotrabeculotomy was performed, in the second group, ab externa sinusotrabeculotomy, cyclodialysis, cycloretraction with autoscleral drainage.

Results. Surgical antihypertensive treatment in stages I–III of the active phase of ROP led to stabilization of the glaucomatous process in 77% of cases; in stages IV–V of the scar phase, satisfactory results were noted in 50%. Moreover, hemorrhagic complications after 18 months led to subatrophy of the eyeball in 2 (50%) cases in patients in the second group of patients.

Conclusion. In the active phase of stages I–III of ROP, hypotensive surgery in the trabecular zone was used; in the cicatricial phase of stages IV–V of ROP, combined hypotensive surgery was used both in the trabecular zone and in the ciliary body area using autoscleral drainage.

Keywords: retinopathy of prematurity; glaucoma; antiglaucomatous surgery; gonioscopy; mesodermal tissue; lensvitreoshwartectomy; hyphema; hemophthalmos; subatrophy of the eyeball; aniridia

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Study concept and design – Khamroeva Yu.A., Khamraeva L.S.; collection and processing of material – Khamroeva Yu.A.; statistical data processing – Khamroeva Yu.A.; writing the text – Khamroeva Yu.A., Khamraeva L.S.; editing – Khamraeva L.S.

For citation: Khamroeva Yu.A., Khamraeva L.S. Treatment of glaucoma associated with retinopathy of prematurity in children. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2024; 12 (2): 44–8. DOI: https://doi.org/10.33029/2308-2402-2024-12-2-44-48 (in Russian)

References

1. Abdolrahimzadeh S., Fameli V., Mollo R., et al. Rare disease leading to childhood glaucoma: epidemiology, pathophysiogenesis, and management. Biomed Res Int. 2015; 2015: 781294. DOI: https://doi.org/10.1155/2015/781294

2. Zertsalova M.A., Brzheskiy V.V. Features of current glaucoma in children with retinopathy of prematurity. Russkiy meditsinskiy zhurnal [Russian Medical Journal]. 2007; 4 (2): 139. (in Russian)

3. Blencowe H., Lawn J.E., Vazquez T., Fielder A., Gilbert C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatr Res. 2013; 74 (1): 35–49. DOI: https://doi/org/10.1038/pr.2013.205

4. Zertsalova M.A., Brzheskiy V.V. Some features of the development of glaucoma in premature babies. Rossiyskaya pediatricheskaya oftal’mologiya [Russian Pediatric Ophthalmology]. 2007; (3): 13–5. (in Russian)

5. Egorova E.A. Glukoma national leadership. Moscow, 2013: 403–4. (in Russian)

6. Makarova M.A., Panchishena V.M., Brusakova E.V., Ershova R.V., Saydasheva E.I., Sokolov V.O. Anatomical features of the angle of the anterior chamber of the eye in children with glaucoma depending on the degree of cicatricial retinopathy of prematurity. Oftal’mologicheskie vedomosti [Ophthalmological Statements]. 2019; 1 (12): 21–6. DOI: https://doi.org/10.17816/OV12121-26 (in Russian)

7. Jameson R.V., Grigg J.R. Clinical embryology and eye development. In: Pediatric Ophthalmology and Strabismus. Vol. 1. Moscow: Izdatel’stvo Panfilova; 2015: 12–22. (in Russian)

8. Konikova O.A., Diskolenko O.V., Gaydar M.V., Brzheskiy V.V. Glaucoma in children against the background of IV and V stages of retinopathy of prematurity: features of the course, outcomes. Rossiyskaya pediatricheskaya oftal’mologiya [Russian Pediatric Ophthalmology]. 2017; 12 (3): 122–6. (in Russian)

9. Kushner B.J. Ciliary block glaucoma in retinopathy of prematurity. Arch Ophthalmol. 1982; 100 (7): 1078–9.

10. Chang S.H.L., Lee Y.S., Wu S.C., See L.S., Chung C.C., Yang M.L., et al. Anterior chamber angle and anterior segment structure of eyes in children with yearly stages of retinopathy of prematurity. Am J Ophthalmol. 2017; 179: 46–54. DOI: https://doi.org/10.1016/j.ajo.2017.04.010

11. Pollard Z.F. Secondary angle-closure glaucoma in cicatricial retrolental fibroplasia. Am J Ophthalmol. 1980; 89: 651–3. DOI: https://doi.org/10.1016/0002-9394(80)90282-2

12. Michael A.J., Pesin S.R., Katz L.J., Tasman W.S. Management of late-onset angle-closure glaucoma associated with retinopathy of prematurity. Ophthalmology. 1991; 98: 1093–8. DOI: https://doi.org/10.1016/S0161-6420(91)32172-9

13. Salgado C., Celik Y., VanderVeen D. Anterior segment complications after diode laser photocoagulation far prethreshold retinopathy of prematurity. Am J Ophthalmol. 2010; 150 (1): 6–9.e2. DOI: https://doi.org/10.1016/j.ajo.2009.12.017

14. URL: https://лазертерапия.рф/stati/glaukoma-u-pacientov-detskogo-vozrasta-struktura-i-klassifikaci

15. Retinopathy of prematurity, active phase. Clinical recommendations of the Russian Federation. Moscow, 2017: 7–8. (in Russian)

16. Shchuko A.G., Yur’eva T.N. Classification of rare forms of glaucoma associated with iris alteration. Chapter 2. Rare forms of glaucoma. Irkutsk, 2021: 31–7. (in Russian)

17. Hoskins H.D. Jr, Shaffer R.N., Hetherington J. Anatomical classification of the developmental glaucomas. Arch Ophthalmol. 1984; 102 (9): 1331–6.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Degtyarev Dmitriy Nikolaevich
Doctor of Medical Sciences, Professor, Deputy Director for Scientific Research of the V.I. Kulakov Obstetrics, Gynecology and Perinatology National Medical Research Center of Ministry of Healthсаre of the Russian Federation, Head of the Chair of Neonatology at the Clinical Institute of Children's Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University, Chairman of the Ethics Committee of the Russian Society of Neonatologists, Moscow, Russian Federation

ORCID iD 0000-0001-8975-2425

Journals of «GEOTAR-Media»