Analysis of vitamin D availability of the physiological course of the perinatal period in mother-newborn couples living in the Khabarovsk Region
AbstractHypovitaminosis D currently represents a public health problem. Worldwide, 54% of pregnant women and 75% of newborns are vitamin D deficient. A severe deficiency was diagnosed in 18 and 29% of cases, respectively.
Objective: to assess the level of vitamin D supply of newborns and their mothers with the physiological course of the perinatal period living in the Khabarovsk Region.
Material and methods. Study design: observational, analytical, cross-sectional. The study included 54 mother–newborn pairs by random sampling: full-term newborns (group 1, n=54) with a conclusion at birth of Z38.0 according to ICD‑10 and mothers of these children (group 2, n=54). During pregnancy, women were divided into age subgroups: early (15–25 years, n=21), middle (26–35 years, n=22) and late (36 years and older, n=11) reproductive period. Quantitative determination of the level of 25-hydroxyvitamin D (25(OH)D) in the serum of umbilical cord (newborns) or venous (mothers) blood was performed by enzyme immunoassay.
Results. When analyzing the concentrations of 25(OH)D in the blood serum of newborns and mothers, it was found that the average value of the calcidiol in the body of newborns was almost 2 times higher than the maternal one (49.8 vs 25.9 ng/ml, respectively, p=0.000). In the group of mothers, the prevalence of vitamin D deficiency and insufficiency was diagnosed in 35.2 and 40.7% of cases, while these rates in newborns were 3.7 and 7.4%, respectively, p<0.001). Low vitamin D status was recorded in 95.2% of young mothers (subgroup 1 of the study), slightly less in the pregnant women of the second subgroup (77.3%), the lowest prevalence of vitamin D deficiency and insufficiency was determined in the group of mothers of the late reproductive period (36.4%) (p=0.003).
Conclusion. Our study revealed a high prevalence of low vitamin D status in the mother group. A moderately positive relationship has been established between the levels of vitamin D in the bodies of newborns and their mothers, which demonstrates the need for adequate vitamin D supply for women during pregnancy.
Keywords:full-term newborns; mothers; calcidiol; vitamin D; 25(OH)D
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
Contribution. Development of the concept and design of the study, methodological support of the study, editing of the article – Senkevich O.A.; statistical data processing, basic analysis and interpretation of data, writing the manuscript – Chebargina M.A.; collection of material, basic analysis and interpretation of data, writing the text of the manuscript – Plotonenko Z.A.; carrying out laboratory diagnostics, writing the text of the manuscript – Kovalsky Yu.G.; review of publications on the topic of the article, writing the text of the manuscript – Gorokhovsky M.V.
For citation: Senkevich О.А., Chebargina M.A., Plotonenko Z.A., Kovalsky Yu.G., Gorokhovskiy M.V. Analysis of vitamin D availability of the physiological course of the perinatal period in mother-newborn couples living in the Khabarovsk Region. Neonatologiya: novosti, mneniya, obuchenie [Neonatology: News, Opinions, Training]. 2023; 11 (3): 22–30. DOI: https://doi.org/10.33029/2308-2402-2023-11-3-22-30 (in Russian)
References
1. Dos Santos S.F., Dos Reis Costa P.N., Gouvêa T.G., et al. Influence of hypovitaminosis D during pregnancy on glycemic and lipid profile, inflammatory indicators and anthropometry of pregnant and newborn. Clin Nutr ESPEN. 2023; 54: 81–93. DOI: https://doi.org/10.1016/j.clnesp.2023.01.005
2. Saraf R., Morton S.M., Camargo C.A. Jr, et al. Global summary of maternal and newborn vitamin D status – a systematic review. Matern Child Nutr. 2016; 12 (4): 647–68. DOI: https://doi.org/10.1111/mcn.12210
3. Treiber M., Mujezinović F., Pečovnik Balon B., et al. Association between umbilical cord vitamin D levels and adverse neonatal outcomes. J Int Med Res. 2020; 48 (10): 300060520955001. DOI: https://doi.org/10.1177/0300060520955001
4. Karras S.N., Wagner C.L., Castracane V.D. Understanding vitamin D metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes. Metabolism. 2018; 86: 112–23. DOI: https://doi.org/10.1016/j.metabol.2017.10.001
5. Mansur J.L., Oliveri B., Giacoia E., et al. Vitamin D: before, during and after pregnancy: effect on neonates and children. Nutrients. 2022; 14 (9): 1900. DOI: https://doi.org/10.3390/nu14091900
6. Zayachnikova T.E., Krasil’nikova A.S., Ostrovsky O.V., et al. Comparative analysis of vitamin D levels in the umbilical cord blood in neonates of different gestational age in the Volgograd region. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta [Bulletin of the Volgograd State Medical University]. 2020; 1 (73): 141–5. (in Russian)
7. Liu W., Xu P. The association of serum vitamin D level and neonatal respiratory distress syndrome. Ital J Pediatr. 2023; 49: 16. DOI: https://doi.org/10.1186/s13052-023-01415-w
8. Kinshella M.-L.W., Pickerill K., Bone J.N., et al. An evidence review and nutritional conceptual framework for pre-eclampsia prevention. Br J Nutr. 2023; 130 (6): 1065–76. DOI: https://doi.org/10.1017/s0007114522003889
9. Palacios C., Kostiuk L.K., Peña-Rosas J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019; 7: CD 008873. DOI: https://doi.org/10.1002/14651858.CD 008873.pub4
10. Sablok A., Batra A., Thariani K., et al. Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome. Clin Endocrinol (Oxf). 2015; 83 (4): 536–41. DOI: https://doi.org/10.1111/cen.12751
11. Tofe-Valera I., Pérez-Navero J.L., Caballero-Villarraso J., et al. Vitamin D deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants. BMC Pregnancy Childbirth. 2023; 23: 23. DOI: https://doi.org/10.1186/s12884-022-05334-2
12. Motlagh A.J., Davoodvandi A., Saeieh S.E. Association between vitamin D level in mother’s serum and the level of vitamin D in the serum of pre-term infants. BMC Pediatr. 2023; 23 (1): 97. DOI: https://doi.org/10.1186/s12887-023-03854-0
13. Bushueva E.V., Levitskaya V.M., Boboeva Sh.G., et al. Vitamin D deficiency and syndrome fetal growth retardation. Mediko-farmatsevticheskiy zhurnal «Pul’s» [Medical and Pharmaceutical Journal «Pulse»]. 2020; 22 (3): 13–7. DOI: https://doi.org/10.26787/nydha-2686-6838-2020-22-3-13-17 (in Russian)
14. Kozgar S.A.M., Chay P., Munns C.F. Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency. BMC Pediatr. 2020; 20: 332. DOI: https://doi.org/10.1186/s12887-020-02204-8
15. Prilutskaya V.A., Sukalo A.V., Dashkevich E.I., et al. Assessment of vitamin D supply in full-term newborns with different body weight at birth: preliminary results. Reproduktivnoye zdorov’e. Vostochnaya Evropa [Reproducive Health Eastern Europe]. 2021; 11 (3): 337–47. DOI: https://doi.org/10.34883/PI.2021.11.3.006 (in Russian)
16. Skriplenok T.N., Prilutskaya V.A., Mokhort T.V. Vitamin D availability in mother–child dyads in type 1 diabetes mellitus. Zdravookhranenie (Minsk) [Healthcare (Minsk)]. 2022: 1 (898): 41–7. (in Russian)
17. Lybzikova N.D., Skriplenok T.N., Prilutskaya V.A. The status of vitamin D availability in large-gestational newborns and their mothers with type 1 diabetes mellitus and without diabetes mellitus. Smolenskiy meditsinskiy al’manakh [Smolensk Medical Almanac]. 2022; (1): 184–8. (in Russian)
18. Nazaretyan V.G., Shanshoeva N. Sh., Mazurenko L.I. Factors involved in vitamin D deficiency development in newborns of Krasnodar krai. Rossiyskiy pediatricheskiy zhurnal [Russian Journal of Pediatrics]. 2022; 3 (1): 214. (in Russian)
19. Verisokina N.E., Klimov L. Ya., Zakharova I.N., et al. Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases. Meditsinskiy sovet [Medical Council]. 2022; (19): 9–20. DOI: https://doi.org/10.21518/2079-701X-2022-16-19-9-20 (in Russian)
20. Malyavskaya S.I., Karamyan V.G., Kostrova G.N., et al. The provision of vitamin D in parturients and newborn infants in the mother-child dyad under the conditions of the subarctic zone of the Russian Federation in the winter season. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2018; (3): 58–62. DOI: https://doi.org/10.18565/aig.2018.3.58-62 (in Russian)
21. Palmrich P., Thajer A., Schirwani N., et al. Longitudinal assessment of serum 25-hydroxyvitamin D levels during pregnancy and postpartum – are the current recommendations for supplementation sufficient? Nutrients. 2023; 15 (2): 339. DOI: https://doi.org/10.3390/nu15020339
22. Tous M., Villalobos M., Iglesias L., et al. Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies. Eur J Clin Nutr. 2020; 74: 36–53. DOI: https://doi.org/10.1038/s41430-018-0373-x
23. Chang S.W., Lee H.C. Vitamin D and health – the missing vitamin in humans. Pediatr Neonatol. 2019; 60: 237–44. DOI: https://doi.org/10.1016/j.pedneo.2019.04.007
24. Wang H., Xiao Y., Zhang L., et al. Maternal early pregnancy vitamin D status in relation to low birth weight and small-for-gestational-age offspring. J Steroid Biochem Mol Biol. 2018; 175: 146–50. DOI: https://doi.org/10.1016/j.jsbmb.2017.09.010
25. Fang K., He Y., Mu M., et al. Maternal vitamin D deficiency during pregnancy and low birth weight: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2021; 34 (7): 1167–73. DOI: https://doi.org/10.1080/14767058.2019.1623780
26. Gamal T.S., Madiha A.-A.S., Hanan M.K., et al. Neonatal and maternal 25-OH vitamin D serum levels in neonates with early-onset sepsis. Children. 2017; 4 (5): 37. DOI: https://doi.org/10.3390/children4050037
27. Saboute M., Yavar R., Kashaki M., et al. Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors. Lipids Health Dis. 2019; 18 (1): 153. DOI: https://doi.org/10.1186/s12944-019-1095-3
28. The Union of Pediatricians of Russia, et al. National program «Vitamin D deficiency in children and adolescents of the Russian Federation: modern approaches to correction». Moscow: Pediatr, 2021: 116 p. (in Russian)
29. Wierzejska R., Jarosz M., Klemińska-Nowak M., et al. Maternal and cord blood vitamin D status and anthropometric measurements in term newborns at birth. Front Endocrinol (Lausanne). 2018; 9: 9. DOI: https://doi.org/10.3389/fendo.2018.00009