Cytokine status of preterm newborns with infectious and noninfectious diseases

• Irina V. Nikitina
• Zhukova A.S.
• Vanko L.V.
• Valentina V. Vtorushina
• Matveeva N.K.
• Lyubov V. Krechetova
• Kryuchko D.S.
• Oleg V. Ionov
• Victor V. Zubkov
• Dmitriy N. Degtyarev

Abstract

Aim. To compare levels of growth factors, chemokines, proinflammatory and anti-inflammatory cytokines in blood in the first day of life of premature newborns with infectious and non-infectious respiratory diseases.

Material and methods. Concentrations of 17 cytokines were examined by multiplex assay in the plasma of peripheral blood of 63 premature newborns in the first day of life.

Results. In the group of newborns with the gestational age (GA) of 32 weeks the concentration of chemokines IL-8 and MSR-1 were higher in subgroup of congenital pneumonia vs. respiratory distress syndrome (RDS). The level of IL-13, IFNγ, IL-12, IL-17, IL-1β, TNF-α, IL-8 and MSR-1 were statistically significant in newborns with early onset sepsis (EOS) versus in subgroup with RDS. Concentration of TNF-α was higher in plasma of infants with EOS in comparison with the newborns in with congenital pneumonia. The level of IL-13 for newborns with GA 32-36 weeks with RDS was higher than in transient tachypnea subgroup. IL-6 and G-CSF's levels were statistically significantly higher in newborns with congenital pneumonia in comparison with the newborns with noninfectious respiratory diseases.

Conclusions. The laboratorial evaluation of blood cytokines can be useful tool for the differential diagnostics of infectious and non-infectious diseases in the early neonatal period

Keywords: cytokines, premature newborn, congenital pneumonia, early onset sepsis

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